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Anti-PRDM5 Antibody
| 产品编号： | 4087607 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PRDM5 Antibody
PR domain zinc finger protein 5, PR domain-containing protein 5
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | PRDM5 is a member of the PR-domain containing family of tumor suppressors. PRDM5 activates histone methyltransferase G9a and class I histone deacetylases to regulate transcription. PRDM5 typically functions as a transcriptional repressor but can also be an activator for endogenous target genes. PRDM5 has often been found to be silenced in human breast, ovarian and liver cancers and and is a candidate biomarker for certain cancers, such as gastrointestinal cancer. Additional studies have also linked the loss of PRDM5 function to the development and pathogenesis of cervical cancer. |
| Immunogen【免疫原】 | Linear peptide corresponding to human PRDM5. |
| Application【应用】 | Use Anti-PRDM5 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect PRDM5 also known as PR domain-containing protein 5. Western Blot Analysis:1 µg/mL from a representative lot detected PRDM5 on 10 µg of HeLa cell lysate and HeLa nuclear extract. |
| Quality【质量】 | Evaluated by Western Blot in PC3 cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected PRDM5 on 10 µg of PC3 cell lysate. |
| Other Notes【其他说明】 | Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | chimpanzee (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_061169 |
| UniProt accession no.【UniProt登记号】 | Q9NQX1 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~75 kDa observed. Three isoforms at 73, 70, and 13 kDa have been described. Uncharacterized bands between 13 and 73 kDa may be observed in some lysates. |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
