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Anti-NLRP12 Antibody
| 产品编号： | 4087742 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-NLRP12 Antibody
NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | NLRP12 (NACHT, LRR and PYD domains-containing protein 12) is also known as Monarch-1 or PYRIN-containing APAF1-like protein 7 (PYPAF7). NLRP12 is thought to mediate activation of CASP1 (via ASC) and NF-kappa-B (via IKK). NLRP12 has been detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes, and is regulated by nitric oxide. NLRP12 defects can cause familial cold autoinflammatory syndrome type 2 (FCAS2). |
| Specificity【特异性】 | Other homologies: Mouse (91% sequence homology). |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human NLRP12. |
| Application【应用】 | Flow Cytometry Analysis: 0.5 µg from a representative lot detected NLRP12 in rat basophil leukemia (RBL). Anti-NLRP12 Antibody is a highly specific rabbit polyclonal antibody, that targets NLRP & has been tested in western blotting & Flow Cytometry. Research Category Signaling Research Sub Category Immunological Signaling |
| Quality【质量】 | Evaluated by Western Blotting in rat basophil leukemia (RBL) cell lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected NLRP12 in 10 µg of rat basophil leukemia (RBL) cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control Rat basophil leukemia (RBL) cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat |
| species reactivity (predicted by homology) | bovine (based on 100% sequence homology), human (immunogen homology) |
| technique(s) | flow cytometry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_150639 |
| UniProt accession no.【UniProt登记号】 | P59046 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... NLRP12(91662) |
产品说明
| Target description【目标描述】 | ~110 kDa observed. Uniprot describes 5 isoforms produced by alternative splicing this antibody recognizes isoforms 1 through 4 at ~120 kDa, ~114 kDa, ~107 kDa, and ~102 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
