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Anti-TIM-1 Antibody
产品编号: | 4087784 |
规格: | from rabbit, purified by affinity chromatography |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-TIM-1 Antibody
Hepatitis A virus cellular receptor 1, HAVcr-1, Kidney injury molecule 1, KIM-1, T-cell immunoglobulin and mucin domain-containing protein 1, TIMD-1, T-cell membrane protein 1, TIM-1, TIM, KIM1, TIM1, TIMD1
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | T-cell immunoglobulin and mucin domain-containing protein 1 (TIMD-1, TIM-1, TIM, TIM1, TIMD1), also known as Hepatitis A virus cellular receptor 1 (HAVcr-1) and Kidney injury molecule 1(KIM-1, KIM1), may play an important role in T-helper cell development and the regulation of asthma and allergic diseases. In the case of human hepatitis A virus (HHAV) infection, TIM-1 functions as a cell-surface receptor for the virus, through which the hepatitis A virus can gain entry into a cell. Additional evidence implies that it may play a role in kidney injury and repair. TIM-1 is widely expressed, with highest levels in kidney and testis. It is also expressed by activated CD4+ T-cells during the development of helper T-cells responses. Furthermore, TIM-1 is expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. |
Specificity【特异性】 | This antibody recognizes the N-terminus of TIM-1. |
Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the N-terminus of human TIM-1. Epitope: N-terminus |
Application【应用】 | Anti-TIM-1 Antibody is a highly specific rabbit polyclonal antibody, that targets T-cell immunoglobulin & mucin domain-containing protein 1 & has been tested in western blotting, IHC & Immunofluorescence. Research Sub Category Immunoglobulins & Immunology Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected TIM-1 in human uterus tissue. Immunofluorescence Analysis: 20 µg/mL from a representative lot detected TIM-1 in human uterus tissue. Research Category Inflammation & Immunology |
Quality【质量】 | Evaluated by Western Blotting in human uterus tissue lysate. Western Blotting Analysis: 1 µg/mL of this antibody detected TIM-1 in 15 µg of human uterus tissue lysate. |
Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
Analysis Note【分析说明】 | Control Human uterus tissue lysate |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
purified by【纯化方式】 | affinity chromatography |
species reactivity | human |
technique(s) | immunofluorescence: suitable immunohistochemistry: suitable western blot: suitable |
UniProt accession no.【UniProt登记号】 | Q96D42 |
shipped in【运输】 | wet ice |
产品说明
Target description【目标描述】 | ~48 kDa observed. Uncharacterized bands may appear in some lysate(s). |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |