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Anti-ZEB1 Antibody
| 产品编号： | 4087791 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-ZEB1 Antibody
Zinc finger E-box-binding homeobox 1, NIL-2-A zinc finger protein, Negative regulator of IL2, Transcription factor 8, TCF-8
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Zinc finger E-box-binding homeobox 1 (ZEB1), also known as Transcription factor 8 (TCF8) and Negative regulator of IL2 or NIL-2-A zinc finger protein is a member of the Zinc finger-Homeobox (ZFH)-family of repressors and acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. ZEB1 has also been implicated in regulating the expression of ATP1A1, E-cadherin, BCL6, and RCOR1 genes. ZEB1 regulates neurogenesis and neuronal differentiation, but is also implicated in tumor formation. ZEB1 is expressed in heart and skeletal muscle. Mutations in ZEB1 have been associated with corneal dystrophy. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human ZEB1. |
| Application【应用】 | Anti-ZEB1 detects levels of ZEB1 proteins & has been published & validated for use in WB. Research Category Epigenetics & Nuclear Function Neuroscience Research Sub Category Transcription Factors Developmental Signaling |
| Quality【质量】 | Evaluated by Western Blot in mouse embryo e11 tissue lysate. Western Blot Analysis: 1.0 µg/mL of this antibody detected ZEB1 in 10 µg of mouse embryo e11 tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control Mouse embryo e11 tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse |
| species reactivity (predicted by homology) | human (immunogen homology), chicken (based on 100% sequence homology), bovine (based on 100% sequence homology), frog (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_110378 |
| UniProt accession no.【UniProt登记号】 | P37275 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~200 kDa observed. The calculated molecular weight is 124 kDa, however ZEB1 has been shown at ~180-210 kDa in western blots (Dave, N., et al. (2011). J. Biol. Chem. 286(14):12024-12032). |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
