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Anti-Nur77 Antibody
| 产品编号： | 4087860 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Nur77 Antibody
Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Nurr77 is an internal nuclear receptor that is expressed developmentally and in the adult in many tissues including the liver, brain and thyroid. In the liver it acts along with other transcription factors to govern liver development as well as regeneration in the adult. Nur77 also participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Nur77 is also a potent pro-apoptotic protein, particularly in the brain and heart where translocation of Nur77 into the mitochondria where it induces apoptosis. Interestingly in certain cancers Nur77 overexpression is associated with pro-oncogenic activity and regulating energy levels which promotes proliferation and survival in cancer cells. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the C-terminus of human Nur77. Epitope: C-terminus |
| Application【应用】 | Research Sub Category Nuclear Receptors Anti-Nur77 is an antibody against Nur77 for use in WB, ICC. Immunocytochemistry Analysis: A 1:1,000 dilution from a representative lot detected Nur77 in HEPG2 cells. Research Category Epigenetics & Nuclear Function |
| Quality【质量】 | Evaluated by Western Blotting in human liver tissue lysate. Western Blotting Analysis: 0.25 µg/mL of this antibody detected Nur77 in 10 µg of human liver tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, human |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_002126 |
| UniProt accession no.【UniProt登记号】 | P22736 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... NR4A1(3164) |
产品说明
| Target description【目标描述】 | ~65 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
