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Anti-PGAM5 Antibody

产品编号:4087913
规格:from rabbit, purified by affinity chromatography
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4087913100 μG6020
产品别名

Anti-PGAM5 Antibody

Serine/threonine-protein phosphatase PGAM5, mitochondrial, Bcl-XL-binding protein v68, Phosphoglycerate mutase family member 5

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
PGAM5 is a mitochondrial specific phosphatase specific for serine/threonine residues. PGAM5 principally dephosphorylates and activates MAP3K5 kinase a critical player in many cancers. PGAM5 also acts as a central mediator for programmed necrosis or necroptosis, induced by TNF, ROS or calcium. In the mitochondria, PGAM5 may also function as a regulator of mitochondrial dynamics and reconstruction. Also PGAM5 functions in the cellular stress response and regulates the removal of damaged mitochondria via mitophagy. PGAM5 itself is regulated at the protein level by the mitochondrial specific rhomboid protease PARL, which cleaves the N-terminal of PGAM5 in response to mitochondrial depolarization.
Specificity【特异性】
This antibody detects the -L(long) isoform and -S(short) isoform of PGAM5.
Immunogen【免疫原】
Epitope: Near N-terminal
KLH-conjugated linear peptide corresponding to human PGAM5 near the N-terminal.
Application【应用】
Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
This Anti-PGAM5 Antibody is validated for use in Western Blotting for the detection of PGAM5.
Quality【质量】
Evaluated by Western Blotting in HT-29 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PGAM5 in 10 µg of HT-29 cell lysate.
Physical form【外形】
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified
Other Notes【其他说明】
Concentration: Please refer to lot specific datasheet.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
chimpanzee (based on 100% sequence homology), hamster (based on 100% sequence homology), monkey (based on 100% sequence homology), primate (based on 100% sequence homology), rodent (based on 100% sequence homology)
technique(s)
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_001164014
UniProt accession no.【UniProt登记号】
Q96HS1
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
~32/34 kDa observed.
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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