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Anti-Rab11-FIP1/RCP Antibody
| 产品编号： | 4087917 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Rab11-FIP1/RCP Antibody
Rab11 family-interacting protein 1, Rab11-FIP1, Rab-coupling protein
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The protein Rab11-FIP1/RCP, or alternatively named Rab11 family-interacting protein 1, or Rab-coupling protein, and encoded by the human gene RAB11FIP1/RCP is an effector protein that interacts with Rab11 in the processes surrounding endosomal recycling. Rab11-FIP1/RCP also is involved in membrane trafficking in phagocytosis, as well as during axon growth, mediating integrin trafficking in various cancers. RAB11-FIP1/RCP has isoforms. Isoform 1 is non-membrane bound and is localized in the endosome and is involved in endosome recycling. Isoform 2 is more cytoplasmic being confined, for example, to the cytoplasmic phagosome vesicles and the phagosome membrane. Rab11-FIP1/RCP is expressed in multiple tissues and comprises one member of a large family of Rab11 family interacting proteins (Fab11-FIPs) that define discrete subdomains and carry out temporally distinct roles within the recycling and membrane trafficking system of the cell. |
| Immunogen【免疫原】 | GST-tagged recombinant protein corresponding to human Rab11-FIP1/RCP. |
| Application【应用】 | Research Sub Category Apoptosis - Additional Research Category Apoptosis & Cancer This Anti-Rab11-FIP1/RCP Antibody is validated for use in western blotting, ICC & IP for the detection of Rab11-FIP1/RCP. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Rab11-FIP1/RCP in 10 µg of C2C12, HEK293, HeLa, HepG2, HUVEC, Jurkat, L6, NIH/3T3, PC-12, PC-3, RAW264.7 cell lysate. Western Blotting Analysis: A representative lot from an independent laboratory detected Rab11-FIP1/RCP in Tac-TGN38 expressing HeLa cell lysates (Jing, J., et al. (2010). Mol Cell Biol. 21(17):3041-3053.). Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Rab11-FIP1/RCP in Tac-TGN38 expressing HeLa cells (Jing, J., et al. (2010). Mol Cell Biol. 21(17):3041-3053.). Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated Rab11-FIP1/RCP from HeLa cell lysate (Jing, J., et al. (2010). Mol Cell Biol. 21(17):3041-3053.). |
| Quality【质量】 | Evaluated by Western Blotting in A431 cell lysate. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Rab11-FIP1/RCP in 10 µg of A431 cell lysate. |
| Physical form【外形】 | Affinity purified Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, mouse, human |
| technique(s) | immunocytochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_001002814 |
| UniProt accession no.【UniProt登记号】 | Q6WKZ4 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... RAB11FIP1(80223) |
产品说明
| Target description【目标描述】 | ~90 kDa observed. Uncharacterized band(s) may be observed in some cell lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
