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Anti-Tet2 Antibody
| 产品编号： | 4087960 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Tet2 Antibody
Methylcytosine dioxygenase TET2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Methylcytosine dioxygenase TET2 catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). The function of 5-hydroxymethylcytosine is currently unclear but it may influence chromatin structure, or act as an intermediate component in cytosine demethylation. TET2 is frequently mutated in myeloproliferative disorders (MPD) or myeloproliferative neoplasms (MPN), and systemic mastocytosis. TET2 disorders also cause polycythemia vera (PV) and myelodysplastic syndrome (MDS). |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human Tet2. |
| Application【应用】 | Anti-Tet2 detects levels of Tet2 proteins & has been published & validated for use in WB, IHC & ICC. Immunohistochemistry Analysis: A 1:4,000 dilution from a representative lot detected Tet2 in rat medulla tissue. Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected Tet2 in human H9 Embryonic Stem cells. |
| Quality【质量】 | Evaluated by Western Blotting in mouse Embryonic Stem cells. Western Blotting Analysis: 1 µg/mL of this antibody detected Tet2 in 10 µg of mouse Embryonic Stem cells (Note: Isoforms 2 and 3 may observed at low concentrations or longer exposure times, while isoform 1 may be detected at higher concentrations or longer exposure times in certain cell lysates.). |
| Other Notes【其他说明】 | Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, rat, mouse |
| technique(s) | immunocytochemistry: suitable immunohistochemistry: suitable (paraffin) western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_060098 |
| UniProt accession no.【UniProt登记号】 | Q6N021 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... TET2(54790) |
产品说明
| Target description【目标描述】 | ~140 kDa observed. Three isoforms at 223 kDa (isoform 1), 130 kDa (isoform 2), and 133 kDa (isoform 3) are known to exist. This antibody should recognize all three isoforms based on sequence homology. An uncharacterized band may be observed at ~36 kDa in some cell lysates. (Note: Isoforms 2 and 3 may observed at low concentrations, while isoform 1 may be detected at higher concentrations in certain cell lysates.) |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
