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Anti-IL-23R Antibody, cytoplasmic
| 产品编号： | 4088103 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μg |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-IL-23R Antibody, cytoplasmic
interleukin 23 receptor
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Interleukin 23 receptor (IL-23R) is a type I cytokine receptor that is a subunit of the receptor for IL23A/IL23. IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. IL-23R associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3. |
| Specificity【特异性】 | This antibody recognizes the cytoplasmic domain of IL-23R. May detect other isoforms of IL-23R (see molecular weight). |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human IL-23R at and around the cytoplasmic domain. |
| Application【应用】 | Anti-IL-23R Antibody, cytoplasmic detects level of IL-23R & has been published & validated for use in WB, IH, ELISA, FC. Does not work for mouse in flow cytometry. Immunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-23R in mouse spleen tissue. Flow Cytometry Analysis: 2-10 µg from a previous lot detected IL-23R in human PBMCs. Does not work in mouse for flow cytometry. ELISA: A previous lot of this antibody was tested on ELISA by an independent laboratory. |
| Quality【质量】 | Evaluated by Western Blot in Jurkat cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected IL-23R on 10 µg of Jurkat cell lysate. |
| Other Notes【其他说明】 | Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, mouse |
| technique(s) | ELISA: suitable flow cytometry: suitable immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_653302 |
| UniProt accession no.【UniProt登记号】 | Q5VWK5 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~42 kDa Observed. May detect other isoforms of IL-23R produced by alternative splicing: isoform 1 (~72 kDa), isoform 2 (~43 kDa), isoform 3 (~41 kDa), isoform 4 (~20 kDa), isoform 5 (~30 kDa), isoform 6 (~43 kDa) and isoform 7 (~26 kDa). |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
