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Anti-Cyclin A Antibody
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Cyclin A is a member of the Cyclin A family that can bind and activate Cdc2 and Cdk2 and is involved in the control of mitosis and S phase. During S phase, cyclin A forms a complex with Cdk2, the pRB-related protein p107 and E2F. |
| Specificity【特异性】 | p58cyclin A; does not cross-react with cyclin B or cyclin D2, or 3 |
| Immunogen【免疫原】 | peptide corresponding amino acid residues 417-432 (C-KHGVSLLNPPETL-N-L) |
| Application【应用】 | Detect Cyclin A with Anti-Cyclin A Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC. Research Sub Category Cell Cycle, DNA Replication & Repair Research Category Epigenetics & Nuclear Function |
| Quality【质量】 | routinely evaluated by immunoblot on HeLa nuclear extract |
| Physical form【外形】 | Protein G Chromatography Lyophilized Format: Purified |
| Analysis Note【分析说明】 | Control Daudi cells |
| Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | human, sheep, mouse, rat |
| manufacturer/tradename | Upstate® |
| technique(s) | immunocytochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG |
| NCBI accession no.【NCBI登记号】 | NM_001237 |
| UniProt accession no.【UniProt登记号】 | P20248 |
| shipped in【运输】 | dry ice |
| Gene Information | human ... CCNA2(890) |
产品说明
| Target description【目标描述】 | 58kDa |
| Storage and Stability【储存及稳定性】 | 2 years at -20°C |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 + H312 + H332 - H412 |
| Precautionary Statements | P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
