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Anti-phospho-TAK1 (Ser412) Antibody
| 产品编号： | 4088231 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-phospho-TAK1 (Ser412) Antibody
Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | TAK1 MAPKKK is activated by TAB1 to transform growth factor-beta (TGF-beta) signaling. TAK1 can also associate with TAB1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. TAK1 has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways. |
| Specificity【特异性】 | This antibody recognizes TAK1 phosphorylated at Ser412. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human TAK1 phosphorylated at Ser412. Epitope: Phosphorylated Ser412 |
| Application【应用】 | Detect phospho-TAK1 (Ser412) using this Anti-phospho-TAK1 (Ser412) Antibody validated for use in WB. |
| Quality【质量】 | Evaluated by Western Blot in lambda phosphatase treated and untreated Murine RAW cell lysates. Western Blot Analysis: 1 µg/mL of this antibody detected TAK1 on 10 µg of lambda phosphatase treated and untreated Murine RAW cell lysates. |
| Analysis Note【分析说明】 | Affinity purified |
| Other Notes【其他说明】 | Control Lambda phosphatase treated and untreated Murine RAW cell lysates |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse, human |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_663306 |
| UniProt accession no.【UniProt登记号】 | O43318 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... MAP3K7(6885) |
产品说明
| Target description【目标描述】 | ~70 kDa observed |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
