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Anti-Rsk1 Antibody
| 产品编号： | 4088547 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μg |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Rsk1 Antibody
90 kDa ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1, Ribosomal S6 kinase 1, Ribosomal protein S6 kinase alpha-1, S6K-alpha 1, p90-RSK 1, Ribosomal protein S6 kinase alpha 1, Ribosomal protein S6 kinase, 90kD, 1, Ribosmal protein S
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Rsk1, Rsk2, and Rsk3 (ribosomal protein S6 kinase, 90kDa, polypeptide 1,2,3; S6K-alpha 1,2,3) are Ser/Thr kinases which are activated by MAP Kinases, and are alternatively referred to as MAPKAP kinases 1a, 1b, and 1c. Following activation, Rsk isoforms translocate to the nucleus, where Rsk2 phosphorylates Ser10 of Histone H3, a critical step in the stimulation of immediate-early gene expression. Rsk1 is able to phosphorylate Ser133 of CREB, activating it as a transcription factor. Rsk1 activation can be monitored by phosphorylation state specific antibodies directed against sites involved in its activation. |
| Specificity【特异性】 | Recognizes p90 RSK1. |
| Immunogen【免疫原】 | Synthetic peptide corresponding to the c-terminal sequence of human p90 RSK1 (C-LAQRRVRKLPSTTL). |
| Application【应用】 | Immunoprecipitation: 4 µg of a previous lot of this antibody was used per 1500 µg of crude protein sample in Immunoprecipitation. ELISA: Recommended. Optimal working dilutions must be determined by end user. Western Blot: A previous lot of this antibody was tested on multiple lysates. See datasheet. Anti-Rsk1 Antibody is an antibody against Rsk1 for use in WB, IP, ELISA. |
| Quality【质量】 | Routinely evaluated by Western Blot on NIH/3T3 lysates. Western Blot Analysis: 1:500-1:1,000 dilution of this lot detected RSK1 on 10 μg of NIH/3T3 lysates. |
| Linkage【联系】 | Replaces: 04-417 |
| Physical form【外形】 | Affinity purified Purified rabbit polyclonal IgG in buffer containing TBS with 0.01% Sodium Azide in 50% glycerol. |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, mouse, human |
| technique(s) | ELISA: suitable immunoprecipitation (IP): suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG |
| NCBI accession no.【NCBI登记号】 | NM_001006665.1 |
| UniProt accession no.【UniProt登记号】 | Q15418 |
| shipped in【运输】 | dry ice |
| Gene Information | human ... RPS6KA1(6195) |
产品说明
| Target description【目标描述】 | 83 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at -20°C in undiluted aliquots from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage. |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
