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Anti-Tie-2 Antibody, NT
| 产品编号： | 4088560 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 50 μg |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Tie-2 Antibody, NT
CD202b antigen, TEK tyrosine kinase, endothelial, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK, soluble TIE2 variant 1, soluble TIE2 variant 2, venous malformations, multip
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Tie-2 is a member of the tyrosine protein kinase family, is a transmembrane receptor for angiopoietin 1, and may represent one of the earliest markers for cell lineage within mammalian endothelial cells. Its expression is almost only found in human, mouse and rat endothelial cells and angioblasts. Most likely, Tie-2 regulates the differentiation, proper dispersal, and proliferation of these cells during angiogenesis. Mutations in TEK are a cause of VMCM or dominantly inherited venous malformations which are characterized by serpiginious, dilated veins. Tie-2 can be found in placenta and lung tissue. Lower levels of the protein can also be found in kidney, umbilical vein endothelial cells, and brain. |
| Specificity【特异性】 | Recognizes human Tunica internal endothelial cell kinase (TIE-2), also described as Angiopoietin-1 receptor, p140 TEK, or tyrosine protein kinase receptor. The peptide sequence used as immunogen is 100% conserved in human, rat, mouse, and 94% in bovine. |
| Immunogen【免疫原】 | 18 amino acid peptide sequence within the extracellular, N-terminus of human Tie-2 |
| Application【应用】 | This Anti-Tie-2 Antibody, N-terminus is validated for use in WB for the detection of Tie-2. Research Sub Category Growth Factors & Receptors Research Category Signaling |
| Quality【质量】 | Evaluated by Western Blot in human brain lysates. Western Blot Analysis: 1:1000 dilution of this lot detected Tie-2 in 10 µg of human brain lysate. |
| Linkage【联系】 | Replaces: AB3126 |
| Physical form【外形】 | Affinity purified immunoglobulin. Liquid in 100 mM Tris, pH 7.5, containing 0.2% BSA and 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control Human brain lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, rat, mouse |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_000450 |
| UniProt accession no.【UniProt登记号】 | Q02763 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | Approx. 126 kDa |
| Storage and Stability【储存及稳定性】 | Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
