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产品别名
Anti-Upf1 Antibody
ATP-dependent helicase RENT1, Nonsense mRNA reducing factor 1, UP Frameshift 1, UPF1 regulator of nonsense transcripts homolog (yeast), Up-frameshift suppressor 1 homolog, delta helicase, regulator of nonsense transcripts 1, up-frameshift mutation 1 homo
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Upf1 is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. Upf1 is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. |
| Specificity【特异性】 | This antibody detects Upf1. |
| Immunogen【免疫原】 | KLH-conjugated synthetic linear peptide corresponding to Upf1. |
| Application【应用】 | Research Sub Category RNA Binding Protein (RBP) Anti-Upf1 Antibody is a rabbit polyclonal antibody for detection of Upf1 also known as ATP-dependent helicase RENT1 ,Nonsense mRNA reducing factor 1, Up-frameshift suppressor 1 homolog & has been validated in WB. Research Category Epigenetics & Nuclear Function |
| Quality【质量】 | Evaluated by western blot on U2OS cell lysate. Western Blot Analysis: 0.5-2 µg/mL of this antibody detected Upf1 in U2OS cell lysate. |
| Physical form【外形】 | Format: Purified Affinity purified Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide. |
| Analysis Note【分析说明】 | Control U2OS cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | human |
| species reactivity (predicted by homology) | bovine, mouse, rat, canine |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_002902.2 |
| UniProt accession no.【UniProt登记号】 | Q92900 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~125 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8ºC from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
