您的位置：首页 > 产品中心 > Anti-eIF4G Antibody
产品别名
Anti-eIF4G Antibody
eIF-4-gamma 1, eIF-4G 1, eukaryotic translation initiation factor 4 gamma 1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | eIF4F is a translation initiation factor containing three subunits: eIF4A, eIF4E, and eIF4G. This complex is a key component in promoting ribosomal binding to the mRNA. eIF4G interacts with both eIF4A and eIF4E though its carboxy and amino terminal domains, respectively. eIF4E binds to the cap structure of the mRNA, while the ATP-dependent RNA helicase eIF4A unwinds the secondary structure of the 5’ UTR. eIF4G plays a critical role in coordinating the assembly of the eukaryotic initiation factors. It acts as a bridge to bind the cap-bound eIF4E, eIF4AI&II, the eIF3 complex, PABP1, and the kinase Mnk1 (Lejeune, F., et al., 2004) in a large eukaryotic initiation factor complex |
| Specificity【特异性】 | Not tested on other species. This antibody detects eIF4G at its N-terminal region. |
| Immunogen【免疫原】 | Synthetic peptide corresponding to N-terminal region of human eIF4G. Epitope: N-terminus |
| Application【应用】 | Research Sub Category RNA Binding Protein (RBP) Insulin/Energy Signaling Anti-eIF4G Antibody is an antibody against eIF4G for use in WB & IF. Research Category Signaling |
| Quality【质量】 | Evaluated by western blot on HeLa cytoplasmic extract. Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect eIF4G in HeLa cytoplasmic extract and lysates from 293T and S10 cells. |
| Physical form【外形】 | Rabbit polyclonal serum with 0.05% NaN3. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | serum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | mouse, human |
| technique(s) | immunofluorescence: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_937884 |
| UniProt accession no.【UniProt登记号】 | Q04637 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 220 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at -20ºC from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
