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Anti-phospho H2A.X (Ser139) Antibody, Alexa Fluor® 647 Conjugate
产品别名
Anti-phospho H2A.X (Ser139) Antibody, Alexa Fluor® 647 Conjugate
Histone H2A.X, Histone H2A.X, H2a/x
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. H2A.X, also known as H2AFX, is a variant of Histone H2A that is found in a subset of nucleosomes. H2A.X has a unique C-terminal tail that becomes phosphorylated following double-stranded DNA breaks following irradiation or apoptosis. Phosphorylation of H2A.X on Ser139 is one of the earliest markers for apoptosis and DNA damage. |
| Specificity【特异性】 | Recognizes Histone H2A.X phosphorylated at Serine 139. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to phospho H2A.X (Ser139). Epitope: Phosphorylated Ser139 |
| Application【应用】 | Research Sub Category Histones Chromatin Biology See data sheet for cat# 07-164, Anti-phospho H2A.X (Ser139) for additional Western blot, Immnoprecipitation, and ChIP-seq analysis performed using an unconjugated version of this antibody. This AlexaFluor Research Category Epigenetics & Nuclear Function Epigenetics & Nuclear Function |
| Quality【质量】 | Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected phospho Histone H2A.X (Ser139) in HeLa cells. Alexa Fluor® is a registered trademark of Life Technologies |
| Physical form【外形】 | Purified conjugated rabbit polyclonal antibody in buffer containing PBS and 15 mg/ml BSA with 0.1% Sodium Azide. Protein A purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
| Legal Information【法律信息】 | ALEXA FLUOR is a registered trademark of Life Technologies |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | ALEXA FLUOR® 647 |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | human |
| species reactivity (predicted by homology) | vertebrates (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable |
| isotype【同位素/亚型】 | IgG |
| NCBI accession no.【NCBI登记号】 | NP_002096 |
| UniProt accession no.【UniProt登记号】 | P16104 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~15 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
