HMPB-MBHA resin

200

Novabiochem^®

beads

reaction type: Fmoc solid-phase peptide synthesis

Novabiochem^®

alcohol

2-30℃

This support consists of MBHA resin functionalized with Riniker′s hyperacid-labile 4-hydroxymethyl-3-methoxyphenoxybutyric acid linker [1].

This hyperacid-sensitive resin is a useful tool for the Fmoc SPPS of protected peptide acid fragments.

Attachment of carboxylic acids is normally achieved by DMAP catalyzed esterification with the appropriate symmetrical anhydride, or by using 2,6-dichlorobenzoyl chloride/pyridine [2] or MSNT/Melm activation [3, 4, 5].

Detachment of these functionalities can be effected by treatment with 1-5% TFA in DCM.

The product number for this product was previously 01-64-0036.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Replaces: 01-64-0036

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.40 - 1.00 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly ( styrene - 1% DVB ) 100- 200 mesh

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

11 - Combustible Solids

WGK 1