Fmoc-Thr(Trt)-OH

C₃₈H₃₃NO₅

583.67

The side-chain Trt group can be selectively removed with 1% TFA in DCM containing 5% TIS, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This is an excellent derivative for the synthesis of phosphothreonine containing peptides and peptides modified at the threonine side-chain [1]. The use of trityl protected amino acids was shown to result in purer products than when standard t-Bu protected amino acids were utilized [2].

The product number for this product was previously 04-12-1141.

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Replaces: 04-12-1141

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 78.0 %
Water (K. F.): ≤ 1.5 %
For TLC-Systems see our General Catalog

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

200

≥78.0% (acidimetric)
≥98% (TLC)
≥98.0% (HPLC)

powder

reaction type: Fmoc solid-phase peptide synthesis

Novabiochem^®

70-85 ℃

peptide synthesis

Fmoc

15-25℃

11 - Combustible Solids

WGK 2