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产品别名
Anti-EED Antibody
embryonic ectoderm development
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Polycomb group proteins are important for maintaining transcriptional silencing. One conserved PcG complex, PRC2, is composed of several proteins including the histone methyltransferase EZH2, the WD-repeat protein EED (Embryonic ectoderm development), and the Zn-finger protein Suz12. Transcriptional repression mediated by EED involves histone deacetylation, while the EZH2 methylates histone H3 on lysine 27. EED protein is present in four isoforms. These EED isoforms selectively associate with distinct EZH2-containing complexes, resulting in differential targeting of their associated methyltransferase activity. These complexes play a role in Hox gene silencing, X-inactivation, germline development, stem cell pluripotency and cancer metastasis. |
| Specificity【特异性】 | This antibody recognizes EED, Mr ~ 62-70 kDa. |
| Immunogen【免疫原】 | A synthetic peptide corresponding to a.a. 429-441 of human EED, conjugated to KLH. Epitope: a.a. 429-441 |
| Application【应用】 | Use Anti-EED Antibody (Rabbit Polyclonal Antibody) validated in WB to detect EED also known as embryonic ectoderm development. |
| Quality【质量】 | Western Blot Analysis: 1 μg/mL of this lot detected EED on 10 μg of Jurkat cell lysate. |
| Linkage【联系】 | Replaces: 09-727 |
| Physical form【外形】 | Purified Format: Purified |
| Analysis Note【分析说明】 | Control Jurkat Cell Lysate 3T3/A31 cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | mouse, human |
| species reactivity (predicted by homology) | opossum, dog, chicken, rat, bovine |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_003788 |
| UniProt accession no.【UniProt登记号】 | O75530 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~53 kDa observed. Uniprot describes three isoforms at 51 kDa (isoform 1), 53 kDa (isoform 2), and 46 kDa (isoform 3). |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
