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Anti-HDAC11 Antibody
| 产品编号： | 4090230 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μg |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-HDAC11 Antibody
histone deacetylase 11
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor. |
| Specificity【特异性】 | This antibody recognizes HDAC11. |
| Immunogen【免疫原】 | Epitope: Amino Acid: 228-246 Linear Peptide corresponding to human HDAC11 at amino acids 228-246. |
| Application【应用】 | Western Blot (SNAP ID) Analysis: 0.5 µg/ml from a representative lot detected HDAC11 on 10 µg of human brain tissue lysate. Anti-HDAC11 Antibody is a Rabbit Polyclonal Antibody for detection of HDAC11 also known as histone deacetylase 11 & has been validated in WB. Research Category Epigenetics & Nuclear Function Research Sub Category Histone Modifying Proteins Cell Cycle, DNA Replication & Repair |
| Quality【质量】 | Evaluated by Western Blot in human brain tissue lysate. Western Blot Analysis: 0.05 µg/ml of this antibody detected HDAC11 on 10 µg of human brain tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control Human brain tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, mouse, rat |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_079103.2 |
| UniProt accession no.【UniProt登记号】 | Q96DB2 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 39 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
