AMPK (α1/β1/γ3), active, His tagged human

200

expressed in baculovirus infected Sf9 cells

PRECISIO^® Kinase

≥70% (SDS-PAGE)

buffered aqueous glycerol solution

157-213 nmol/min·mg

A1 subunit ~68 kDa
B1 subunit ~38 kDa
G3 subunit ~51 kDa

Q13131
Q9UGI9
Q9Y478

dry ice

−70℃

human ... PRKAA1(5562), PRKAB1(5564), PRKAG3(53632)

AMPK (A1/B1/G3) is a member of the AMPK family which are heterotrimeric proteins consisting of an α catalytic subunit, and non-catalytic β and γ subunits. AMPKs are an important energy-sensing enzyme group in the cells that monitor energy status particularly in response to stress. AMPKs regulate fatty acid and cholesterol synthesis by regulating the key rate-limiting enzymes acetyl-CoA carboxylase and 3-hydroxy-3-methylglutaryl-CoA reductase. The γ subunit is dominantly expressed in skeletal muscle where it may play a key role in the regulation of energy metabolism.

Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

GHS08

Danger

H360D

P201 - P202 - P280 - P308 + P313 - P405 - P501

Repr. 1B

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 1