您的位置：首页 > 产品中心 > Human Chondrocytes-Osteoarthritis: HC-OA, adult
Human Chondrocytes-Osteoarthritis: HC-OA, adult
基本信息
| NACRES | NA.81 |
| General description【一般描述】 | HC-OA Human Chondrocytes are derived from human articular cartilage of donors with osteoarthritis (OA). Osteoarthritis is an inflammatory disease characterized by increased degradation of cartilage tissue in the joint due to overproduction of enzymes degrading the extracellular matrix. Despite the initial proliferation and activation of chondrocytes, they are not able to efficiently repair the degrading cartilage. Instead, chondrocytes undergo terminal differentiation and eventually apoptose, leading to mineralization of cartilage in a process resembling bone formation during development. Thus, HC-OA provide a useful model to study changes in chondrocyte biology in response to abnormal environment of the OA joint. Characterization: Positive for aggrecan after differentiation. HC-OA have been used to demonstrate that THF-alpha activates transcription of ADAMTS-4, a metalloproteinase implicated in cartilage degradation in OA, via p38-MAPK-dependent mechanism (Xue, 2013). |
| Cell Line Origin【细胞系来源】 | Cartilage |
| Application【应用】 | model for studying chondrocyte biology in an osteoarthritis joint |
| Components【组分】 | Basal Medium containing 10% FBS & 10% DMSO |
| Preparation Note【制备说明】 |
|
| Subculture Routine【传代培养常规】 | Please refer to the HC-OA Culture Protocol. |
产品性质
| biological source【生物来源】 | human articular cartilage (osteoarthritic) |
| Quality Level【质量水平】 | 100 |
| packaging【包装】 | pkg of 500,000 cells |
| growth mode【生长模式】 | Adherent |
| karyotype【核型】 | 2n = 46 |
| morphology【形态学】 | chondrocyte |
| technique(s) | cell culture | mammalian: suitable |
| relevant disease(s)【相关疾病】 | arthritis |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −196℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
