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Anti-CD4 (Mouse), PE-Cy7, clone RM4-5 Antibody
产品别名
Anti-CD4 (Mouse), PE-Cy7, clone RM4-5 Antibody
T-cell surface glycoprotein CD4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, CD4, CD4
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.44 |
| General description【一般描述】 | The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The RM4-5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the RM4-5 antibody and an alternative antibody, Anti-Mouse CD4 clone GK1.5, will “compete” for binding, i.e. RM4-5 antibody is able to block GK1.5 antibody binding to cells. In contrast, RM4-5 antibody does not block the binding of Anti-Mouse CD4 clone RM4-4 to cells. |
| Application【应用】 | This rat monoclonal Anti-CD4 Antibody (Mouse), PE-Cy7, clone RM4-5, Cat. No. MABF1572 is validated for use in Flow Cytometry, for the detection of CD4. |
| Quality【质量】 | This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. Flow Cytometry Analysis: 0.06 μg from a representative lot detected CD4 in one million C57Bl/6 splenocytes. |
| Other Notes【其他说明】 | Purified by size-exclusion chromatography |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | rat |
| conjugate【偶联物】 | PE-Cy7 |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | RM4-5, monoclonal |
| species reactivity | mouse |
| packaging【包装】 | antibody small pack of 25 μg |
| technique(s) | flow cytometry: suitable |
| isotype【同位素/亚型】 | IgG2aκ |
| UniProt accession no.【UniProt登记号】 | P06332 |
产品说明
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
