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ODQ-CAS 41443-28-1-Calbiochem
产品编号: | 4090828 |
规格: | A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC50 = 20 nM). |
CAS NO: | 41443-28-1 |
包装规格: | 10 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4090828 | 10 MG | 3280 |
产品别名
41443-28-1
ODQ-CAS 41443-28-1-Calbiochem
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
基本信息
Empirical Formula【经验(实验)分子式】 | C9H5N3O2 |
Molecular weight | 187.15 |
MDL number | MFCD00792620 |
General description【一般描述】 | A potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC50 = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ fails to inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase. A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC50 = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ does not inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target (NO)-sensitive guanylyl cyclase Product does not compete with ATP. Target IC50: 20 nM against nitric oxide (NO)-sensitive guanylyl cyclase Reversible: yes |
Warning【警告】 | Toxicity: Irritant (B) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
Other Notes【其他说明】 | Wang, D., et al. 1998. J. Biol. Chem. 273, 33027. Southam, E., et al. 1996. Br. J. Pharmacol. 119, 527. Brunner, F., et al. 1995. FEBS Lett.376, 262. Garthwaite, J., et al. 1995. Mol. Pharmacol.48, 184. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (TLC and HPLC) |
form【形式】 | powder |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | light yellow |
solubility【溶解性】 | DMSO: 25 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
InChI | 1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H |
InChI key | LZMHWZHOZLVYDL-UHFFFAOYSA-N |
packaging【包装】 | 10 mg in Plastic ampoule |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |