您的位置：首页 > 产品中心 > Monoclonal Anti-phospho-β-Catenin (pSer33) antibody produced in mouse
Monoclonal Anti-phospho-β-Catenin (pSer33) antibody produced in mouse
| 产品编号： | 4091608 |
| 规格： | clone BC-76, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD04040943 |
| NACRES | NA.41 |
| General description【一般描述】 | Cateninβ is a multifunctional protein, coded by CTNNB1 (cateninβ 1) gene. It is present in the intracellular side of the cytoplasmic membrane. It is located on human chromosome 3p22.1. |
| Immunogen【免疫原】 | synthetic phosphopeptide corresponding to the region that contains serine 33 of human β-catenin. |
| Application【应用】 | Monoclonal Anti-phospho-β-Catenin (pSer33) antibody produced in mouse is suitable for microarray and western blotting at a concentration of 5μg/mL using total cell extracts of cultured HEK-293T cells treated with MG132. |
| Biochem/physiol Actions【生化/生理作用】 | Catenin (cadherin-associated protein), β 1 (88kDa) protein is encoded by CTNNB1 gene in humans. It is also called as β-catenin. It is a dual function protein that regulates the coordination of cell-cell adhesion and gene transcription. Human β-catenin is located at band p21 on chromosome 3. Mutations in β-catenin results in retinal vascular condition FEVR (familial exudative vitreoretinopathy). It participates in stimulating disease progression, providing BCR–ABL (fusion gene) kinase-independent resistance and LSC (leukemic stem cell) self-renewal. CTNNB1 plays an important role in cell-to-cell adhesion and transcriptional modulation in the Wnt signalling pathway. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | BC-76, monoclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | microarray: suitable western blot: 5 μg/mL using total cell extracts of cultured HEK-293T cells treated with MG132 |
| isotype【同位素/亚型】 | IgM |
| UniProt accession no.【UniProt登记号】 | P35222 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CTNNB1(1499) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
