18:1-12:0 NBD PA

C₃₉H₆₈N₅O₁₁P

813.96

NA.25

Phosphatidic acid (PA) is a simple anionic membrane phospholipid. The amphipathic phospholipid contains a polar head group and two long hydrophobic acyl chains. NBD PA is a fluorescent probe containing 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) linked to the sn-2 fatty acid of PA.

18:1-12:0 NBD PA or 1-oleoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt) has been used in donor liposomes for phosphatidic acid (PA) transfer activity assay. It might be used:in the preparation of PA small unilamellar vesicles (SUVs) to determine mammalian target of rapamycin complex 1 (mTORC1) lysosomal translocation. It may be used in NBD-PA and NBD phosphatidyl choline uptake assays and to measure lipid transfer specificity of Ups1 mutants

Phosphatidic acid (PA) is crucial for intracellular signaling involved in various cellular processes, including membrane trafficking and sperm hyper-activation. PA reacts with water and other phospholipids to produce lipid bilayers and multicomponent bilayers, respectively.

>99% (TLC)

Avanti Polar Lipids 810176C

1 mg/mL (810176C-1mg)

dry ice

−20℃

5 mL Amber Glass Screw Cap Vial (810176C-1mg)

GHS06,GHS08

Danger

H302 - H315 - H319 - H331 - H336 - H351 - H361d - H372 - H412

P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Central nervous system

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK 3