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磷酸二酯酶 5A1 人
Phosphodiesterase 5A1 human
产品别名
磷酸二酯酶 5A1 人
Phosphodiesterase 5A1 human
PDE 5A1
3′,5′-cyclic-GMP phosphodiesterase
基本信息
| Enzyme Commission (EC) Number【酶学委员会(EC)编号】 | 3.1.4.25 ( BRENDA | IUBMB ) |
| NACRES | NA.54 |
| Application【应用】 | Phosphodiesterase (PDE) is an enzyme that is used to breaks phosphodiester bonds. PDE5 is a molecular target for the treatment of erectile dysfunction and pulmonary hypertension. PDE5 is used to find novel PDE5 inhibitors . |
| Biochem/physiol Actions【生化/生理作用】 | PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis . |
| Physical properties【物理属性】 | N-terminal GST-tagged 126 kDa full-length protein |
| Unit Definition【单位定义】 | One unit will convert 1.0 picomole of 3′,5′-cGMP to 5′-GMP per minute at pH 7.4 at 37 ℃. |
| Physical form【外形】 | Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% TWEEN® 20 and 3 mM DTT |
| Legal Information【法律信息】 | TWEEN is a registered trademark of Croda International PLC |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in Sf9 cells |
| form【形式】 | solution |
| Specific Activity | ≥2,000 unit/μg protein |
| mol wt【分子量】 | 126 kDa |
| UniProt accession no.【UniProt登记号】 | O76074 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... PDE5A(8654) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 3 |
