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Prostaglandin F Synthase human
| 产品编号： | 4092524 |
| 规格： | recombinant, expressed in E. coli, ≥90% (SDS-PAGE) |
| CAS NO： | 55976-95-9 |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
55976-95-9
Prostaglandin F Synthase human
indanol dehydrogenase
aldo-keto reductase family 1 member C3
AKR1C3
17-beta-hydroxysteroid dehydrogenase type 5
基本信息
| Enzyme Commission (EC) Number【酶学委员会(EC)编号】 | 1.1.1.188 ( BRENDA | IUBMB ) |
| NACRES | NA.54 |
| Application【应用】 | Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma . |
| Biochem/physiol Actions【生化/生理作用】 | PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways . |
| Unit Definition【单位定义】 | One unit is defined as the amount of enzyme required to produce 1 μmol of NADP per minute at 37℃ in 50 mM KPO4 pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in E. coli |
| description【描述】 | contains a C-terminal hexahistidine tag |
| Assay【测定】 | ≥90% (SDS-PAGE) |
| form【形式】 | liquid |
| Specific Activity | ≥0.4 μmol/mg protein |
| mol wt【分子量】 | ~37 kDa |
| NCBI accession no.【NCBI登记号】 | NP_003730 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... AKR1C3(8644) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
