Phenylsulfanyltetrafluorobromoethane

C₈H₅BrF₄S

MFCD27996155

Phenylsulfanyltetrafluoroethyl bromide is a fluoroalkylbromide that is a radical source of the phenylsulfanyltetrafluoroethyl moiety. Alternatively, it can also be selectively metallated at the fluorinated carbon with Turbo Grignard reagent at low temperatures resulting in a thermally unstable anion that can act as a nucleophilic fluoroalkylation reagent towards a wide variety of electrophiles, such as aldehydes, ketones or sulfonylimines. A phenylsulfanyltetrafluoroethyl moiety incorporated in the substrate can be treated with tributyltin hydride and generate the corresponding fluoroalkyl radical. If the substrate lacks any olefins, it can be reduced to tetrafluoroethyl group whereas if the substrate contains an olefin in a correct spatial orientation, it can lead to an intramolecular cyclization affording tetrafluorinated cyclic structures.

Technology Spotlight: Fluoroalkylation: Expansion of Togni Reagents

Product of CF Plus Chemicals.

liquid

GHS07

Warning

H319 - H413

P273 - P305 + P351 + P338

Aquatic Chronic 4 - Eye Irrit. 2

10 - Combustible liquids