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苏拉明钠盐-CAS 129-46-4-Calbiochem
Suramin, Sodium Salt-CAS 129-46-4-Calbiochem
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4093778 | 50 MG | 862 |
产品别名
129-46-4
苏拉明钠盐-CAS 129-46-4-Calbiochem
Suramin, Sodium Salt-CAS 129-46-4-Calbiochem
P2Y Antagonist I, Purinergic Receptor P2Y Antagonist I, PTP Inhibitor VI
PTP Inhibitor VI, Purinergic Receptor P2Y Antagonist I, P2Y Antagonist I
基本信息
Empirical Formula【经验(实验)分子式】 | C51H34N6O23S6 · 6Na |
Molecular weight | 1429.17 |
MDL number | MFCD00210217 |
General description【一般描述】 | An anti-neoplastic, anti-angiogenic agent that uncouples G-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerase I and II. Inhibits Ca2+-ATPase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors including EGF, PDGF, and TGF-β. An inhibitor of phospholipase D (IC50 = 15 µM). Reported to interact with ATP-binding enzymes and P2-purinergic receptors. An effective inhibitor of angiogenesis in calmodulin assays when given in combination with angiostatic steroids. A reversible and competitive inhibitor of protein tyrosine phosphatases. An anti-neoplastic, anti-angiogenic agent that uncouples G-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. Inhibits GDP-GTP exchange, the rate limiting step in the activation of Gα-subunits. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerases I and II. Inhibits Ca2+-ATPase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors, including EGF, PDGF, and TGF-β. An inhibitor of phospholipase D (IC50 = 15 µM). Reported to interact with ATP-binding enzymes and P2-purinergic receptors. An effective inhibitor of angiogenesis in the calmodulin assay when given in combination with angiostatic steroids. |
Biochem/physiol Actions【生化/生理作用】 | Primary Target protein tyrosine phosphatases Target IC50: 15 µM against phospholipase D Product does not compete with ATP. Cell permeable: no Reversible: yes |
Warning【警告】 | Toxicity: Standard Handling (A) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. |
Other Notes【其他说明】 | Meyers, M.O., et al. 2000. J. Surg. Res. 91, 130. Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346. Waldhoer, M., et al. 1998. Mol. Pharmacol. 53, 808. Zhang, Y.L., et al. 1998. J. Biol. Chem. 273, 12281. Hohenegger, M., et al. 1996. Mol. Pharmacol. 50, 1443. Emmick, J.J., et al. 1994. J. Pharmacol. Exp. Ther. 269, 717. Denhertog, A., et al. 1992. J. Physiol.454, 591. Nakajima, M., et al. 1991. J. Biol. Chem.266, 9661. Wilks, J.W., et al. 1991. Int. J. Radiat. Biol.60, 73. Huang, R.C., et al. 1990. Mol. Pharmacol.37, 304. Kopp, R. and Pfeiffer, A. 1990. Cancer Res.50, 6490. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | crystalline solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
color【颜色】 | white |
solubility【溶解性】 | water: 5 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | 2-8℃ |
InChI | 1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6 |
InChI key | VAPNKLKDKUDFHK-UHFFFAOYSA-H |
packaging【包装】 | 50 mg in Plastic ampoule |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |