L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride-CAS 159190-44-0-Calbiochem

C₇H₁₅N₃O₂ · 2HCl

246.13

Cell permeable. Approximately five times more potent as an inhibitor of endothelial nitric oxide synthase (IC₅₀ = 500 nM) than other arginine analogs, such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine induced relaxation of rat aorta rings (IC₅₀ = 2 µM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC₅₀ = 19.5 mg/kg).
A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase (eNOS; IC₅₀ = 500 nM) compared to other arginine analogs such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine-induced relaxation of rat aorta rings (IC₅₀ = 2 µM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC₅₀ = 19.5 mg/kg).

Cell permeable: yes
Primary Target
eNOS
Target IC₅₀: 500 nM against endothelial nitric oxide synthase (eNOS); 2 µM against acetylcholine-induced relaxation of rat aorta rings; EC50 = 19.5 mg/kg for a dose-dependent increase in mean arterial blood pressure in the rat
Product does not compete with ATP.
Reversible: no

Toxicity: Irritant (B)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
Rees, D.D., et al. 1990. Br. J. Pharmacol.101, 746.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (TLC)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

white

water: 1 mg/mL

ambient

−20℃

20 mg in Plastic ampoule

11 - Combustible Solids

WGK 3