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PIH-CAS 737-86-0-Calbiochem
产品价格
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4094473 | A cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class. | 2650 |
产品别名
737-86-0
PIH-CAS 737-86-0-Calbiochem
pyridoxal isonicotinoyl hydrazone, Iron Chelator III
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H14N4O3 |
| Molecular weight | 286.29 |
| General description【一般描述】 | A cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2,3-dioxygenase activity. A cell-permeable, non-toxic, iron (Fe3+) chelator of the aroyl hydrazone class that exhibits high chelation efficacy. Highly effective in mobilizing Fe3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Desferrioxamine (Cat. No. 252750) but has greater access to mitochondrial iron. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Reported to useful in studies of the management of iron overload disease. Inhibits the induction of heme-containing indoleamine 2,3-dioxygenase activity. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C. |
| Other Notes【其他说明】 | Buss, J.L., et al. 2002. Biochem. Pharmacol.64, 1689. Thomas, S.R., et al. 2001. J. Immunol.166, 6332. Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta1523, 154. Blaha, K., et al. 1998. Blood11, 4368. Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med.131, 306. Richardson, D.R.,et al. 1995. Blood86, 4295. Richardson, D.R., et al. 1994. J. Lab. Clin. Med.124, 660. Ponka, P., et al. 1988. Biochim. Biophys. Acta967, 122. Ponka, P., et al. 1984. Biochim. Biophys. Acta802, 477. Ponka, P., et al. 1979. FEBS Lett.97, 317. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥99% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 5 mg/mL slighlty acidic medium: soluble |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C14H14N4O3/c1-9-13(20)12(11(8-19)6-16-9)7-17-18-14(21)10-2-4-15-5-3-10/h2-7,17,19H,8H2,1H3,(H,18,21)/b12-7+ |
| InChI key | HOYFGBFEIXEDEL-KPKJPENVSA-N |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
