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产品别名
XIAP, active
Baculoviral IAP repeat-containing protein 4 (BIRC4), IAP-like protein, Inhibitor of apoptosis protein 3 (API3)
基本信息
| eCl@ss | 32160405 |
| NACRES | NA.41 |
| General description【一般描述】 | X-linked inhibitor of apoptosis (XIAP) is one of a group of intracellular proteins which have been shown to act as endogenous inhibitors of caspases, the enzymatic effectors of apoptosis. XIAP possesses a C-terminal RING domain that functions as an E3 ubiquitin ligase and is able to ubiquitinate a variety of substrates thereby affecting a broad range of cellular activities beyond apoptotic suppression. There is evidence that XIAP plays a significant role in cell division, morphogenesis, heavy metal homeostasis, NF-kB activation and MAP kinase signalling. XIAP expression has been shown to be elevated in several malignancies and so is considered a promising target in anticancer therapies. |
| Application【应用】 | Ubiquitination Cascade Comoponent: E3 |
| Physical form【外形】 | Purified using glutathione sepharose, followed by gel filtration |
| Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | human |
| manufacturer/tradename | Upstate® |
| technique(s) | activity assay: suitable |
| NCBI accession no.【NCBI登记号】 | NM_001167 |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364 |
| Hazard Classifications【危险分类】 | Skin Sens. 1 |
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
