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Macrophage Colony-Stimulating Factor from mouse
| 产品编号： | 4094810 |
| 规格： | M-CSF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture |
| CAS NO： | 81627-83-0 |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4094810 | 10 μG | 4400 |
产品别名
81627-83-0
Macrophage Colony-Stimulating Factor from mouse
mCSF-1
mM-CSF
CSF-1
M-CSF
基本信息
| EC number【EC 号】 | 214-684-5 |
| MDL number | MFCD00166591 |
| eCl@ss | 32190102 |
| Quality【质量】 | endotoxin tested |
| Application【应用】 | Macrophage Colony-Stimulating Factor from mouse has been used:
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| Biochem/physiol Actions【生化/生理作用】 | Macrophage Colony Stimulating Factor (M-CSF), also known as CSF-1, can be produced by a number of cells, including fibroblasts, monocytes, activated macrophages, secretory epithelial cells of the endometrium, endothelial cells activated by LPS or cytokines, and bone marrow stromal cells. In addition to its namesake activity, M-CSF can stimulate the proliferation of isolated macrophages, augment the production and release of cytokines and other inflammatory modulators from macrophages, enhance macrophage antibody-dependent cell-mediated cytotoxicity, prime and enhance macrophages in their ability to kill tumor cells and other microorganisms, stimulate pinocytosis, and support osteoclast differentiation. M-CSF binds and activates a 165 kDa glycoprotein of the receptor tyrosine kinase subclass III or the RTK subfamily. Due to alternative splicing of a single M-CSF gene and due to variations in glycosylation, the molecular weight of natural soluble M-CSF ranges from 44-86 kDa. Human and mouse M-CSF share approximately 80% sequence homology in the conserved N-terminal region of 150 amino acids. Although human M-CSF is active in murine systems, mouse M-CSF appears to be species-specific in its actions. |
| Physical form【外形】 | Lyophilized from a sterile filtered buffered aqueous solution. |
| Analysis Note【分析说明】 | The proliferative activity is tested by the dose-dependent stimulation of the murine monocytic cell line, M-NFS-60. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | 0.500-3.000 ng/mL ED50 |
| mol wt【分子量】 | dimer 18.2 kDa (containing 156 amino acid residues) |
| packaging【包装】 | pkg of 10 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | ≤1.000 EU/μg |
| color【颜色】 | white |
| UniProt accession no.【UniProt登记号】 | P07141 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | mouse ... Csf1(12977) |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P261 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 2 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
