您的位置：首页 > 产品中心 > S-methyl-5′-thioadenosine phosphorylase human
S-methyl-5′-thioadenosine phosphorylase human
基本信息
| Enzyme Commission (EC) Number【酶学委员会(EC)编号】 | 2.4.2.28 ( BRENDA | IUBMB ) |
| NACRES | NA.54 |
| Application【应用】 | S-methyl-5′-thioadenosine phosphorylase human (MTAP) is an enzyme used in cancer research that is deficient in many types of cancer. Decreased MTAP expression may be used as a potential indicator of disease progression of gastrointestinal stromal tumors . MTAP may be a used to develop potential therapeutic strategies for hepatocellular carcinoma (HCC) since MTAP inactivation has been linked to HCC development and invasiveness . |
| Biochem/physiol Actions【生化/生理作用】 | MTAP expression is crucial for the catabolism of methylthioadenosine, which is a by-product of polyamine biosynthesis in the methionine salvage pathway. Protein expression is decreased by homozygous deletion and promoter hypermethylation . |
| Physical properties【物理属性】 | N-terminal GST-tagged 57 kDa protein containing amino acids 2-end. |
| Physical form【外形】 | Supplied as a solution in 25 mM Tris-HCl, pH 8.0,100 mM NaCl, 0.05% Tween®-20, 10% glycerol,and 3 mM DTT. |
| Legal Information【法律信息】 | TWEEN is a registered trademark of Croda International PLC |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥80% (SDS-PAGE) |
| form【形式】 | solution |
| relevant disease(s)【相关疾病】 | cancer |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
