Cisplatin-CAS 15663-27-1-Calbiochem

Pt(NH₃)₂Cl₂

MFCD00011623

NA.77

A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
A platinum coordination complex with potent antineoplastic activity.



Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Induces apoptosis in cancer cells

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Unstable in solution; reconstitute just prior to use.

Hall, M.D., et al. 2014. Cancer Res. In press.
Duan, L., et al. 2001. J. Neurooncol.52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother.16, 279.
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CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze

yellow

PBS with 140 mM NaCl: 1 mg/mL
water with 154 mM NaCl: 1 mg/mL
DMSO: 10 mg/mL

ambient

2-8℃

1S/2Cl.2H3N.Pt/h;;2*1H3;

JFUARQHXOQHNLK-UHFFFAOYSA-N

50 mg in Glass bottle

GHS06,GHS08

Danger

H300 - H315 - H317 - H319 - H334 - H335 - H350

P202 - P261 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Respiratory system

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK 3