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PhotoClick Cholesterol

产品编号:4095536
规格:Hex-5′-ynyl 3β-hydroxy-6-diazirinyl-5α-cholan-24-oate, powder
CAS NO:1485490-47-8
包装规格:100 μG,250 μG
产品类别:进口试剂
品牌:Avanti
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4095536100 μG2670
4095536250 μG5150
产品别名

1485490-47-8

PhotoClick Cholesterol

hex-5-yn-1-yl 4-((3S,5S)-3-hydroxy-10, 13-dimethyl-1,2,3,4,5,7,8,9,10,11,12,13,14,15,16,17-hexadecahydrospiro[cyclopenta[a]phenanthrene-6,3′-diazirin]-17-yl)pentanoate

基本信息
Empirical Formula【经验(实验)分子式】
C30H46N2O3
Molecular weight
482.70
NACRES
NA.25
General description【一般描述】
PhotoClick Cholesterol is a clickable, photoreactive sterol probe for use in combination with quantitative mass spectrometry to globally map cholesterol-protein interactions directly in living cells. In addition to the UV-activatable cross-linking diazirine group that reacts with proteins, the sterol contains an alkyne group for incorporation of reporter and affinity tags through click-chemistry.
PhotoClick Cholesterol is a synthetic analog of cholesterol and is photoreactive. It comprises the alkyne group.
Application【应用】
PhotoClick Cholesterol has been used:
  • in lysosome-associated membrane protein 1 (LAMP1) crosslinking studies
  • as an analog of cholesterol in binding and competition assay of sterol binding proteins from yeast
  • as a conjugate with the ectodomain of lysosomal integral membrane protein-2 (LIMP-2)

Biochem/physiol Actions【生化/生理作用】
PhotoClick Cholesterol serves as a probe for tracking cholesterol-binding proteins. The copper-catalyzed azide-alkyne cycloaddition is the basis for its probe functionality. The alkyne group is essential for the click chemistry property. Its binding to partners is mediated by photocrosslinking.
产品性质
Assay【测定】
>99% (TLC)
form【形式】
powder
manufacturer/tradename
Avanti Polar Lipids 700147P
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
packaging【包装】
2 mL Amber Serum Vial with Stopper and Crimp Cap (700147P-250ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (700147P-100ug)
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
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