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Sphingosine Kinase 1 人
Sphingosine Kinase 1 human
产品别名
Sphingosine Kinase 1 人
Sphingosine Kinase 1 human
SPHK 1
SPHK 2
基本信息
| Enzyme Commission (EC) Number【酶学委员会(EC)编号】 | 2.7.1.91 ( BRENDA | IUBMB ) |
| MDL number | MFCD09265456 |
| NACRES | NA.54 |
| General description【一般描述】 | Sphingosine 1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis. |
| Application【应用】 | Sphingosine kinase 1 has been used in a study to assess the modulation of cellular S1P levels. Sphingosine kinase 1 has also been used in a study to investigate how FTY720 normalizes hyperglycemia. |
| Biochem/physiol Actions【生化/生理作用】 | Converts sphingosine to sphingosine-1-phosphate. SPHK1 shares two large conserved regions with SPHK2. While SPHK1 is found only in the cytosol, SPHK2 is localized in both the cytosol and nuclei. |
| Unit Definition【单位定义】 | One unit will produce 1.0 pmole of sphingosine-1-phosphate from ATP and D-erythro-sphingosine per minute at pH 7.4, 37 ℃. |
| Physical form【外形】 | aqueous glycerol solution Supplied in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween 20, 50% glycerol, 3 mM DTT. |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in baculovirus infected insect cells |
| form【形式】 | solution |
| Specific Activity | ≥10 units/μg |
| mol wt【分子量】 | 47 kDa |
| UniProt accession no.【UniProt登记号】 | Q9NYA1 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... SPHK1(8877) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
