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Ubiquitin Carrier Protein H3/CDC34 human
| 产品编号： | 4099886 |
| 规格： | ≥95% (SDS-PAGE), recombinant, expressed in E. coli overproducing strain |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD03101856 |
| NACRES | NA.56 |
| Biochem/physiol Actions【生化/生理作用】 | Infected cell protein 0 of herpes simplex virus 1 was shown to bind UbcH3 and induce its degradation by promoting its polyubiquination. This resulted in increased expression of an UbcH3-target gene cyclin D1 and aided in further viral infection. Cdc34 is an essential gene for viability in yeast. Cdc34 mediates the transition from G1 to S-phase of the cell cycle by degrading the S-phase cyclin/CDK inhibitor, SIC1 in yeast and p27(KIP1) in human. Cdc34 is also known to interact with the Skp1/Cdc53/F-box (SCF) ubiquitin ligase subunits Cul1 to degrade the NF-κB inhibitor IκBα in a phosphorylation-dependent manner. |
| Physical form【外形】 | Solution in 50 mM HEPES, 200 mM NaCl, 1 mM TCEP (pH 7.5), and 10% glycerol. |
| Other Notes【其他说明】 | Manufactured for Sigma by Boston Biochem. Inc. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli overproducing strain |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | solution |
| mol wt【分子量】 | ~32 kDa |
| UniProt accession no.【UniProt登记号】 | P49427 P61088 |
| application(s) | cell analysis |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... CDC34(997), UBE2N(7334) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
