Phosphodiesterase 4B2, His·Tag^®, Human, Recombinant, S. frugiperda

liquid

100

≥0.25 U/μL

Calbiochem^®

OK to freeze
avoid repeated freeze/thaw cycles

wet ice

−70℃

10 u in Plastic ampoule

Full-length, recombinant, human phosphodiesterase 4B2 (accession no. L20971) fused at the N-terminus to a His•Tag sequence and expressed in S. frugiperda using a baculovirus expression system. Plays a significant role in the regulation of inflammatory cell activation. PDE4B2 is a predominant isoform in neutrophils and monocytes. Supplied as a partially purified, catalytically active preparation.

Toxicity: Standard Handling (A)

One unit is defined as the amount of enzyme that will convert 1 pmol cAMP to AMP per min at 30°C, pH 7.5.

In 150 mM NaCl, 10 mM Tris, 0.1% NP-40, pH 8.3.

Following initial thaw, aliquot and freeze (-70°C).

Gibson, L.C.D., et al. 2006. Eur. J. Pharmacol.538, 39.
Smith, P.G., et al. 2005 Blood105, 308.
Baroja, M.L., et al. 1999. J. Immunol.162, 2016.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany

12 - Non Combustible Liquids

WGK 1