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Wee1, active from rat
基本信息
| MDL number | MFCD03459055 |
| Application【应用】 | Wee1, active from rat may be used to study apoptotic signaling. |
| Biochem/physiol Actions【生化/生理作用】 | Wee1 is a protein tyrosine kinase that phosphorylates Cdc2 on Tyr15 and hence inactivates the CDK1 and CDK2, which facilitates in the negative regulation of entry of cells into mitosis. Increased level of wee1 stimulates Human Immunodeficiency Virus type 1 (HIV-1) Vpr induced cell cycle arrest at G2/M transition followed by apoptosis. Protein inhibitor of Cdk2 kinase |
| Unit Definition【单位定义】 | One unit of Wee 1 is defined as the amount of Wee 1 which inhibits 90% of the activity of 10 units of Cdk2 |
| Physical form【外形】 | Solution in 50 mM Tris-HCl, pH 7.5, 1 mM EDTA, 1 mM DTT, 10% Glycerol |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | rat |
| recombinant【重组】 | expressed in E. coli |
| form【形式】 | solution |
| mol wt【分子量】 | ~110 kDa |
| UniProt accession no.【UniProt登记号】 | Q63802 |
| application(s) | cell analysis |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | rat ... Wee1(308937) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
