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Anti-53BP1 Antibody, clone BP13
产品别名
Anti-53BP1 Antibody, clone BP13
p53 Binding Protein 1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, and maintaining genomic stability. It is sequence specific transcription factor that plays a central role in the the response of mammalian cells to genotoxic stress. Also, 53BP1 localizes to kinetochores in mitotic cells, suggesting a potential function in mitotic checkpoint signaling. |
| Specificity【特异性】 | 53BP1 |
| Immunogen【免疫原】 | Recombinant human 53BP1 proteins. |
| Application【应用】 | Detect 53BP1 also known as p53 Binding Protein 1 with Anti-53BP1 Antibody, clone BP13 (Mouse Monoclonal Antibody) validated in IF & WB. Research Category Epigenetics & Nuclear Function Research Sub Category Cell Cycle, DNA Replication & Repair Western blot. Recognizes a protein of >250 kD. Suggested dilution buffer is TBST. Suggested blocking buffer is 5% non-fat dry milk. Immunoprecipitation. Expected size in immunoblot is >250 kD. Suggested lysis buffer is NETN. Suggested capture agent is Protein A + rabbit anti-mouse linker antibody. Optimal working dilutions must be determined by the end user. |
| Physical form【外形】 | Purified immunoglobulin. Liquid in PBS, containing sodium azide. Format: Purified |
| Legal Information【法律信息】 | CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | BP13, monoclonal |
| species reactivity | human |
| manufacturer/tradename | Chemicon® |
| technique(s) | immunofluorescence: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1 |
| NCBI accession no.【NCBI登记号】 | NM_005657.1 |
| UniProt accession no.【UniProt登记号】 | Q12888 |
| shipped in【运输】 | wet ice |
产品说明
| Storage and Stability【储存及稳定性】 | Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
