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Phorbol 12-myristate 13-acetate
产品别名
Phorbol 12-myristate 13-acetate
PMA
TPA
4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
12-O-Tetradecanoylphorbol 13-acetate
基本信息
| eCl@ss | 32160405 |
| NACRES | NA.41 |
| Application【应用】 | Phorbol 12-Myristate 13-Acetate is suitable as an inducer of cell differentiation in monocytic cell lines such as U937 and THP-1. |
| Biochem/physiol Actions【生化/生理作用】 | Phorbol 12-Myristate 13-Acetate is a tumor-promoting phorbol ester. It regulates various processes such as gene transcription, cellular growth and differentiation, apoptosis, the immune response, and receptor desensitization via activating protein kinase C (PKC) signaling pathways. It promotes differentiation of human monocytic THP-1 cells to functional macrophages. |
| Physical form【外形】 | C36H56O8 |
| Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| manufacturer/tradename | Upstate® |
| technique(s) | activity assay: suitable (kinase) |
| shipped in【运输】 | wet ice |
产品说明
| Storage and Stability【储存及稳定性】 | 2 years at -20°C |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Pictograms【象形图】 | GHS05,GHS06,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H300 + H310 + H330 - H315 - H318 - H351 |
| Precautionary Statements | P201 - P202 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Skin Irrit. 2 |
| Storage Class Code【储存分类代码】 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
