咪唑

C₃H₄N₂

68.08

103853

MFCD00005183

free-flowing

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.

Imidazole has been used

• in the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein
• in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography
• as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells

特别适用于 pH 6.2-7.8 范围内的缓冲液

Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).

Redi-Dri is a trademark of sigma-aldrich Co. LLC

100

for molecular biology

<1 mmHg ( 20 ℃)

Redi-Dri^™

≥99% (titration)

crystalline powder

6.2-7.8 (25 ℃)

6.95

256 ℃ (lit.)

88-91 ℃ (lit.)

diagnostic assay manufacturing

DNase, RNase and protease, none detected

c1c[nH]cn1

1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)

RAXXELZNTBOGNW-UHFFFAOYSA-N

GHS05,GHS07,GHS08

Danger

H302 - H314 - H360D

P201 - P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338 + P310 - P308 + P313

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 2

293.0 °F - closed cup

145 ℃ - closed cup