您的位置：首页 > 产品中心 > Anti-APC Antibody, NT, clone Ali 12.28
Anti-APC Antibody, NT, clone Ali 12.28
产品别名
Anti-APC Antibody, NT, clone Ali 12.28
Adenomatous polyposis coli protein
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The adenomatous polyposis coli tumor suppressor gene is mutated (often deletion of the C-terminal portion of APC) in the inherited disease, familial adenomatous polyposis (FAP), and over 80% of colorectal cancers. Ali 12-28 can be used for APC expression and detection of APC mutations. |
| Specificity【特异性】 | Recognizes human APC, molecular weight ~310 kDa, as well as C-terminal truncation mutants containing the epitope mapped between amino acids 135 to 422. |
| Immunogen【免疫原】 | N-terminal APC-MBP fusion protein (first 1.3 kb of APC which includes the first 433 aa and the first 9 exons of the gene). Epitope: N-terminus |
| Application【应用】 | Research Sub Category Cell Cycle, DNA Replication & Repair Western blot: 4 μg/mL Immunohistochemistry (Acetone Fixed, Frozen) ELISA Immunoprecipitation Optimal working dilutions must be determined by end user. Research Category Epigenetics & Nuclear Function Use Anti-APC Antibody, N-terminus, clone Ali 12.28 (Mouse Monoclonal Antibody) validated in ELISA, IP, WB, IHC to detect APC also known as Adenomatous Polyposis Coli Protein. |
| Linkage【联系】 | Replaces: AB1268 |
| Physical form【外形】 | Format: Purified Purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide. |
| Analysis Note【分析说明】 | Control POSITIVE CONTROL: SW480, LoVo, DLD1, and SW837 cell lines |
| Legal Information【法律信息】 | CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | Ali 12.28, monoclonal |
| species reactivity | human |
| should not react with | mouse |
| manufacturer/tradename | Chemicon® |
| technique(s) | ELISA: suitable immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1 |
| NCBI accession no.【NCBI登记号】 | NM_000038.3 |
| UniProt accession no.【UniProt登记号】 | P25054 |
| shipped in【运输】 | wet ice |
产品说明
| Storage and Stability【储存及稳定性】 | Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
