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Anti-p130cas/BCAR1 Antibody, clone 2C1.1
产品别名
Anti-p130cas/BCAR1 Antibody, clone 2C1.1
Breast cancer anti-estrogen resistance protein 1, Cas scaffolding protein family member 1, Crk-associated substrate, p130Cas
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Breast cancer anti-estrogen resistance protein 1 (UniProt P56945; also known as Cas scaffolding protein family member 1, Crk-associated substrate, p130Cas) is encoded by the BCAR1 (also known as CAS, CAS1, CASS1, CRKAS) gene (Gene ID 9564) in human. p130Cas/BCAR1 is an adaptor protein that belongs to the CAS family of scaffold proteins, members of which also include Nedd9, HEF-1 (CAs-L), EFS, and CASS4. Structurally, p130Cas is composed of a Src-homology 3 (SH3) domain, an adjacent large substrate-binding domain containing 15 repetitions of the YxxP motif, a main site of tyrosine phosphorylation on the p130Cas/BCAR1 molecule that generates SH2-binding sites, a proline and serine rich region, and a highly conserved four-helix bundle (focal adhesion targeting [FAT] domain). p130Cas/BCAR1 plays an important role in transducing signaling originated from mechanical stimuli, extracellular matrix (ECM) adhesion, as well as growth factor stimulation cascades during normal development and diseases. |
| Specificity【特异性】 | Expected to react with all eight spliced isoforms of human p130Cas reported by UniProt (P56945-1 through P56945-8). |
| Immunogen【免疫原】 | GST-tagged recombinant human p130cas/BCAR1 C-terminal fragment. |
| Quality【质量】 | Evaluated by Western Blotting in A431 cell lysate. Western Blotting Analysis: A 1:2,000 dilution of this antibody detected p130cas/BCAR1 in 10 µg of A431 cell lysate. |
| Physical form【外形】 | Purified by Ion-Exchange Chromatography Format: Purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 2C1.1, monoclonal |
| species reactivity | human |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgMκ |
| NCBI accession no.【NCBI登记号】 | NP_055382 |
| UniProt accession no.【UniProt登记号】 | P56945 |
| shipped in【运输】 | dry ice |
| Gene Information | human ... BCAR1(9564) |
产品说明
| Target description【目标描述】 | ~93 kDa observed. 93.14-97.88 kDa (isoforms 1-3 and isoforms 5-8) and 77.73 kDa (isoform 4) calculated. Fully phosphorylated target band migrates with an apparent molecular size of ~130 kDa |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
