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IGF-Binding Protein 6 human
| 产品编号： | 4102950 |
| 规格： | recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture |
| 包装规格： | 20 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
IGF-Binding Protein 6 human
IBP-6
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | The IGFBP6 (insulin-like growth factor-binding protein 6) gene is mapped to human chromosome 12q13. It belongs to the IGFBP family of proteins. The protein has a IGF (insulin-like growth factor)-binding site and a thyroglobulin type-1 domain. IGFBPs are mainly required to regulate IGFs activities. IGFBP6 strongly interacts with IGF-2, but also interacts with IGF-1. It is also a hypoxia-inducible gene. Recombinant human IGF-BP6 has a calculated mass of 22.3kDa and consists of 213 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. |
| Biochem/physiol Actions【生化/生理作用】 | IGFBP6 (insulin-like growth factor-binding protein 6) can suppress growth of various IGF-2 (insulin-like growth factor 2)-dependent tumors. However, it also exhibits IGF-independent activities. IGFBP is suggested as a serum biomarker for proliferative vitreoretinopathy. HIV (human immunodeficiency virus) infection results in downregulation of IGFBP6 via differential methylation. |
| Sequence【序列】 | RCPGCGQGVQ AGCPGGCVEE EDGGSPAEGC AEAEGCLRRE GQECGVYTPN CAPGLQCHPP KDDEAPLRAL LLGRGRCLPA RAPAVAEENP KESKPQAGTA RPQDVNRRDQ QRNPGTSTTP SQPNSAGVQD TEMGPCRRHL DSVLQQLQTE VYRGAQTLYV PNCDHRGFYR KRQCRSSQGQ RRGPCWCVDR MGKSLPGSPD GNGSSSCPTG SSG |
| Physical form【外形】 | Lyophilized from 10 mM Sodium Citrate, pH 3.5. |
| Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in (BTI-Tn-5B1-4) High-5 Insect Cells |
| Assay【测定】 | ≥95% (HPLC) ≥95% (SDS-PAGE) |
| form【形式】 | lyophilized |
| potency【效能】 | 0.1-0.4 μg/mL |
| mol wt【分子量】 | 23.0-30.0 |
| packaging【包装】 | pkg of 20 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | <0.1 EU/μg endotoxin, tested |
| color【颜色】 | white to off-white |
| UniProt accession no.【UniProt登记号】 | P24592 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IGFBP6(3489) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
