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IGF-Binding Protein-3 human
| 产品编号： | 4102952 |
| 规格： | recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture |
| 包装规格： | 25 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
IGF-Binding Protein-3 human
Growth-hormone-dependant binding protein
IBP-3
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | IGFBPs (insulin-like growth factor-binding proteins) are mainly required to regulate IGFs (insulin like growth factors) activities. IGFBP3 is a multifunctional protein and is secreted by various cells. It is most ample circulating IGFBP and works in IGF-dependent and -independent mechanisms. The IGFBP3 gene is mapped to human chromosome 7p12.3. Recombinant human IGF-BP3 is a 28.8kDa protein consisting of 264 amino acid residues. |
| Application【应用】 | IGF-Binding Protein-3 human has been used to study its association with follicular fluid and subsequent effect on embryo development. |
| Biochem/physiol Actions【生化/生理作用】 | IGFBP3 (insulin-like growth factor-binding protein 3) is involved in cell survival as well as cell death and tumorigenesis. Epigenetic changes in IGFBP3 affect non-small-cell lung cancer, hepatocellular carcinoma, ovarian cancer, skin cancer, urological cancers, breast cancer and gastric cancer. IGFBP3 is a primary growth inhibitor and can reverse the mitogenic functions of IGF-1 (insulin like growth factor 1) by inducing apoptosis. IGF-BP3 is a 30 kDa cysteine-rich secreted protein. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues. |
| Sequence【序列】 | GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK |
| Physical form【外形】 | Lyophilized from 20mM HCl. |
| Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥98% (HPLC) ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized |
| potency【效能】 | ≤0.2 μg/mL |
| mol wt【分子量】 | 28.8 kDa |
| packaging【包装】 | pkg of 25 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | <0.1 EU/μg endotoxin, tested |
| color【颜色】 | white to off-white |
| UniProt accession no.【UniProt登记号】 | P17936 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IGFBP3(3486) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
