IL-17E human

human

expressed in HEK 293 cells

6-His tagged (C-terminus)

≥95% (SDS-PAGE)

lyophilized powder

calculated mol wt 16.7 kDa
observed mol wt 27 kDa
observed mol wt 31 kDa
observed mol wt 4 kDa (DTT-reduced. Protein migrates due to different glycosylation.Tyr 33 is the predicted N-terminus .)

pkg of 10 μg

<1 EU/μg endotoxin (LAL test)

Q9H293

wet ice

−20℃

human ... IL-17E(64806)

Interleukin 25 (IL25) also known as Interleukin-17E (IL-17E), is a distinct member of the IL17 cytokine family comprised of at least six members sharing a conserved cysteine-knot structure but divergent at the N-terminus. IL-25 is secreted by type 2 helper T cells (Th2) and mast cells. IL25 can induce NF-κB activation, and stimulate the production of IL8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17RB. IL-25 induces the production of other cytokines, including IL-4, IL-5 and IL-13 in multiple tissues, which stimulate the expansion of eosinophils. This cytokine is an important molecule controlling immunity of the gut and has been implicated in chronic inflammation associated with the gastrointestinal tract. IL-25 can kill some types of breast cancer cells.

Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

11 - Combustible Solids

WGK 3