TACI human

NA.32

TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells). TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Recombinant human TACI is a soluble 159 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein.

Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM NaCitrate, pH 4.0 and 150 mM NaCl.

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

human

expressed in E. coli

≥98% (SDS-PAGE)

lyophilized powder

17.8 kDa

pkg of 10 μg
pkg of 50 μg

<1 EU/μg endotoxin (LAL test)

O14836

wet ice

−20℃

human ... TACI(23495)

13 - Non Combustible Solids

WGK 3